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KMID : 0043320120350111895
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Archives of Pharmacal Research
2012 Volume.35 No. 11 p.1895 ~ p.1901
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Design, synthesis, and biological evaluation of novel 1, 2, 4-triazole derivatives as antifungal agent
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Chai Xiaoyun
Yu Shichong
Jiang Yongwei
Zou Yan
Wu Qiuye
Zhang Dazhi
Jiang Yuanying
Cao Yongbing
Sun Qingyan
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Abstract
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A series of novel 1, 2, 4-triazole derivatives (9a?p) have been designed and synthesized as the potential antifungal agents. All compounds were characterized by 1H-NMR, 13C-NMR, and LCMS. Their antifungal activities against seven human pathogenic fungi were evaluated in vitro by measuring the minimal inhibitory concentrations. Most of the tested compounds were found to be more potent against Candida albicans than the control drug fluconazole.
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KEYWORD
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Triazole, Synthesis, Antifungal activity, CACYP51, Molecular docking
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